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Understanding 5-Amino-1MQ Peptide Therapy 5-Amino-1MQ functions as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly active in fat tissue and linked to obesity and type 2 diabetes
10.1016/j.orcp.2021.02.002 45 RothM.OrijaI
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Mapping of early signaling events in tumor necrosis factor alpha-mediated lipolysis in human fat cells
By blocking NNMT activity, the compound preserves nicotinamide availability for the NAD+ salvage pathway, leading to 1.2- to 1.6-fold increases in intracellular NAD+ concentrations
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