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[89] indicated that 2M was increased in COPD patients and was correlated with lower pulmonary diffusing capacity values, increased alveolar wall/septal thickening (fibrosis changes), and higher expressions of TGF-1, Smad4, and a-SMA

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It's just about like the most completely humbling experience that I've ever had." [175] Keaton never married, and referenced her mother's experiences as a wife as one of the key factors in that decision

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Raising the cost of cigarettes has been proven to reduce their consumption