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Comparing serial concentrations of CSEs for inflammatory response, 3R4F and Spectrum cigarettes showed a dose-dependent increasing trend in TNF- release from THP-1 derived macrophages (Supplementary file Figure 5) until the 15% and 30% dilution, respectively (only moderate cytotoxicity was observed at this dilution in BEAS-2B cells)

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Approximately 40% of individuals who lack a high school diploma smoke, compared to 10% of those with a college degree