In many cases, this has clear links to its physiological functions
At this point it cannot be ruled out that some of the proteins that were captured with monothiol glutaredoxin mutants as Grx(SSR) species might have just accumulated as unspecific dead-end products
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Once in the cytosol, the mature toxin forms a complex with preprotoxin molecules that have not yet been imported into the ER, which can be ubiquitinated and then proteasomally degraded, protecting the cell from the lethal effects of the -subunit
Clinical study also has demonstrated that patients with acute myocardial infarction show a significant increase of IL-1 plasma levels (39)