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Even the Royal College of Midwives suggest in their Support to Quit Smoking in Pregnancy Position Statement that If a pregnant woman who has been smoking chooses to use an e-cigarette (vaping) and it helps her to quit smoking and stay smokefree, she should be supported to do so

We repeated this permutation procedure 1000 times to generate a range of estimated effects and checked to see how likely the estimated effect obtained from the model using real JUUL market entry dates could happen

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Because they are made in advance, users dont need to do it themselves