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Cafes and restaurants are enclaves where smoking is embraced, augmenting the social allure of tobacco
In fact, a single large cigar can contain as much tobacco as an entire pack of cigarettes
Pathophysiology Problematic (chronic) tobacco use (eg, tobacco use disorder) involves complex physiological and psychosocial mechanisms: Physiological (ie, dependency): Nicotine strongly binds nicotinic acetylcholine receptors (nAChRs), primarily in the mesolimbic dopamine pathway
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