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In addition, antioxidants may interfere with regulators of cell proliferation such as extracellular signal-regulated kinase 1/2 (ERK1/2), cyclin-dependent kinases regulating the cell cycle (Kim et al

Armstrong AJ, Marengo MS, Oltean S, Kemeny G, Bitting RL, Turnbull JD, Herold CI, Marcom PK, George DJ, Garcia-Blanco MA

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Inhibition of GCH1 reduced BH4 and resulted in enhanced erastin-induced iron accumulation and lipid peroxidation, thereby enhancing ferroptosis sensitivity, while BH4 supplementation suppressed ferroptosis-related changes caused by GCH1 downregulation

10.1016/S1286-4579(02)01549-6

It is given together with hormonal anticancer therapies