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Cotinine, the primary nicotine breakdown product, is commonly tested for in nicotine screening tests, along with other related substances, because it remains in the body longer than nicotine itself

These 3 randomized clinical trials including 775 participants with affective disorders, opioid use disorder, or socioeconomic disadvantage found that reducing nicotine content significantly decreased total cigarettes smoked daily and nicotine dependence severity

7 (July 2010): 91732

Rates of cigarette smoking vary widely, and have changed considerably over the course of history

1 Smokers are more than 20 times more likely to develop lung cancer than nonsmokers

& Kolonel, L