Over age, the body's ability to produce glutathione decreases
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Without a glucagon arm, semaglutide does not directly offset that decline
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Detailed blood transfusion history (age of start transfusion, pre-transfusion Hb, simple and exchange transfusion, frequency per year and the complications as regards alloimmunization and infections), drug history including HU (age of start in years, maximum dose/kg/day, duration, compliance, and side effects), iron chelation (age of start in years, type, dose, duration, compliance, and side effects) was recorded