They can be very unsightly and cause considerable
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Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy
Oral doses used in animal studies are typically three to ten times higher than equivalent injectable doses to produce comparable systemic effects suggesting oral bioavailability in the range of 1030% relative to parenteral delivery.3 That does not mean oral BPC-157 is ineffective
Parra-Peralbo E, Talamillo A, Barrio R
Rapid acetylators were competent in isoniazid acetylation but the drug was cleared less efficiently in the slow acetylator group, which resulted in elevated serum concentration and led to adverse neurologic side effects due to an accumulation of unmetabolized drug (Brockton et al., 2000)
