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Archived from the original on 10 July 2015

Several studies have shown that prenatal, early postnatal, and adolescent brain maturation is physiologically regulated by acetylcholine (ACh) via activation of nicotinic acetylcholine receptors (nAChRs), and that nicotine exposure results in significant long-term deficits in the developing brain by interfering with the cholinergic regulatory processes ( Given the susceptibility of the developing brain to nicotine as outlined above, preventing tobacco product use among youth is critical to ending the tobacco epidemic in the United States

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"Hawaii set to become first state to raise smoking age to 21"