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SURPASS-CN-MONO is a randomized, double-blind, placebo-controlled phase III study designed to evaluate the efficacy and safety of tirzepatide monotherapy compared to placebo in people with type 2 diabetes

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Even at the level of the median eminence, specific binding sites for IGF-I have been identified where it acts by inhibiting GHRH secretion [161, 162]

Mounce BC, Cesaro T, Carrau L, Vallet T, Vignuzzi M