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In 2025, the noted decreases in the prevalence of alcohol consumption among youth continued a long-term decline that has taken place over nearly three decades and is significantly lower than peak years recorded in the early to mid-1990s, when tracking this data began

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In the study evaluating tobacco effects on the course of PEP it was found that current smoking was independently protective against PEP (35)

to 21 could prevent 223,000 premature deaths, 50,000 deaths from lung cancer, and 4.2 million years of life lost