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Various cancer cell lines, human keratinocytes, and epithelial cells all have 7 nAChR and respond to NNK exposure (EC50 for NNK= 0.03 M)

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Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults

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UVB, UVA & VL or visible light can stimulate pigment production, resulting in rebound back to the natural skin color