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The researchers used genomic data from 472,174 UK Biobank participants, related to current smokers, those who never smoked, and for people who had smoked previously

Diabetes 66(11):28882902

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Discussion As mentioned above, tobacco interferes with drug metabolism essentially by the action of PAH that have effects through the induction of CYP 1A1, CYP1A2 and CYP2E1 [9]

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