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H3K18la activates NF-B signaling and increases SASP factors such as IL-6 and IL-8, accelerating brain aging and AD progression (Wei et al., 2023)

This is called melasma or the "mask of pregnancy." It usually shows up on the cheeks, forehead, or upper lip

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This review systematically describes the multi-target mechanisms of SIRT1 in MASLD pathogenesis through its regulation of critical factors, including peroxisome proliferator-activated receptor gamma coactivator 1-, Forkhead Box O, and nuclear factor kappa-light-chain-enhancer of activated B cells, which govern hepatocyte lipid remodeling, mitochondrial quality control, autophagyendoplasmic reticulum stress balance, and Kupffer cell/T cell polarization

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