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To target certain brain regions for electrical stimulation and regulation during DBS, an electrode is implanted in specific brain regions and high-frequency electrical stimulation (100200 Hz) is delivered to mimic the effect of a lesion without destroying brain tissue

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The Declaration of Helsinki (1964) : The World Medical Association refined these rules, introducing Independent Ethics Committees

Friends, family members, or hairstylists often notice changes that self-observation misses

The model development was done using non-linear mixed-effect modeling (NONMEM, edition 7, ICON Development Solutions, Ellicott City, MD, USA)

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