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Exclusion criteria were as follows: age less than 20 years

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Current neuropharmacology , 14 (8), 857-865

Others experience it as a loss of pleasure or mild emotional flatness around food. Trial mood scores moved slightly better rather than worse, so the negative experience appears to be a minority signal that standard adverse-event tables do not capture well

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found that G6PD-d mice spontaneously developed pulmonary hypertension secondary to increased VSMC proliferation