A strong jet of water striking the powdered lyophilizate directly can mechanically damage (denature) the sensitive peptide structure
Individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2) should discuss this with their clinician before considering any GLP-1based therapy, and should be alert to symptoms such as a neck lump, hoarseness, or difficulty swallowing
A subset of cultured cells expressed GLP- 1 receptor, and mice with a-cell specific GLP- 1 receptor knockout have mild glucose intolerance and higher glucagon secretion in response to glucose challenges than animals of the wild type, which may indicate that GLP- 1 directly affects this cell [69]
On LPS contamination: A real concern under specific conditions
While MIC B12 injections are generally considered safe, they may cause mild side effects such as redness or soreness at the injection site
JAMA Internal Medicine, 180 (3), 458-459