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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

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MOTS-c (short for mitochondrial open-reading-frame of the 12S rRNA type-c) is often dubbed a mitokine a peptide hormone produced by mitochondria that influences metabolism throughout the body

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PMID 35337622