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Hepatocyte growth factor induces DNA synthesis and proliferation of vascular endothelial cells through the activation of ERK and STAT3 (Dong et al., 2001
Lana, J
There are two groups of targeted therapy: small-molecule inhibitors and monoclonal antibodies
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In vitro and animal studies have found that lipoic acid exhibits immunomodulatory properties through mechanisms that stimulate the production of cyclic AMP (cAMP) (90, 91) a central regulator of innate immune functions and inhibits the migration of immune cells into the brain and spinal cord (92), possibly by decreasing endothelial expression of cell adhesion molecules, inhibiting expression of enzymes like matrix metalloproteinases (MMP), and/or reducing the permeability of the blood-brain barrier (87, 89, 93, 94)
