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Assessing glucose homeostasis, employing the oral glucose tolerance test (oGTT), showed an impaired glucose metabolism in WT relative to symptomatic aged 5xFAD mice (Supplementary Fig

BSO, which augments glutamate levels, also increased mEPSC frequency (Fig

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This result may be due to the low percentage of functional thyroid tissue in children with cretinism in which T4 is converted to active T3 at the periphery in the presence of Se supplementation only