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When CYP1A2 (Phase I) oxidizes an aromatic amine to its N-hydroxy derivative, and then O-acetyltransferase activity (catalyzed by the same NAT enzymes) transfers an acetyl group to the oxygen, it creates a highly reactive N-acetoxyarylamine that binds DNA

The critical difference between symptom suppression and addressing the underlying disease process

J Intern Med 253:240243 McClain CJ, Price S, Barve S, Devalarja R, Shedlofsky S (1999) Acetaminophen hepatotoxicity: an update

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