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The structurally simplified Ang IV peptidemimetic 16 was almost as active as Ang IV as an IRAP inhibitor while 17 was five-fold and 18 and the open chain 19 were 20-fold less active (Figure 5)

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The Weibull distribution model demonstrated that upper limits of 95% CIs of were all below 1 (Table S6), consistent with an early failure profile, indicating NAEs predominantly manifest during initial treatment phases

Clinical development is designed to address these knowledge gaps

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