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That off-label status was established in FDAs 2014 epidural corticosteroid drug safety communication, issued April 23, 2014, which required label changes warning of rare but serious neurologic events

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Another question that needs resolution is how does high blood sugar level trigger OS and lead to cardiovascular dysfunction

doi:10.1016/j.celrep.2018.06.096 97

Can we "micro-type" people to improve pharmacokinetics and/or reduce toxicity