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Some patients require NAD injections 1-2 times per week, while other patients require 3-10 injections per week

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EMG/NCS to assess nerve function

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Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learningand motor coordination in hyperammonemic rats

These limited reports suggest good tolerability, though the small sample sizes, lack of standardized safety monitoring, and retrospective or uncontrolled study designs limit definitive safety conclusions