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Behind the surface, rosacea involves a mix of factors: the immune system is more reactive, the skin barrier is weaker, and blood vessels respond more easily to triggers

DMT1 is a key protein regulating iron balance, and DMT1 inhibitors have been reported to selectively target CSCs in primary cancer cells and circulating cancer cells, causing ferroptosis in breast cancer CSCs and reversing multidrug resistance through lysosomal iron accumulation and ROS production

J Lumin 129:536540

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This results in oxygen-deprived areas within the tumor tissue

3.2 MAPKAPK2 overexpression mitigates H2O2-triggered cellular toxicity as well as restores melanogenic capacity within melanocytes affected by vitiligo To evaluate the cytoprotective function of MAPKAPK2 under oxidative insult conditions, PIG3V cells were exposed to H 2 O 2 and transfected with either an empty vector or MAPKAPK2-expressing plasmid