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10.1161/01.CIR.0000109496.82683.49 Circulation 165 ShimamuraM.SatoN.WaguriS.UchiyamaY.HayashiT.IidaH.et al (2006)

Temporary Fatigue or 'Flush' Feeling: Some users report a brief period of feeling tired or flushed shortly after administration as the body processes the peptide

Highly effective for countering the damage done by painkillers (NSAIDs) and treating intestinal permeability (Leaky Gut)

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SOD: copper-zinc SOD (Cu/Zn SOD), mainly present in the Graafian follicle and manganese SOD (MnSOD) concentrated mainly in the corpus luteum (124)

Studies have confirmed that Irisin is a protein-like myokine secreted during exercise, derived from fibronectin type III domain-containing protein 5 (FNDC5) (Ma et al., 2025