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While primarily studied for its roles in autoimmune conditions, PEPITEM influence on immune cell behavior has implications for bone healing because the inflammatory phase of fracture repair depends heavily on coordinated immune cell activity

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The aging process also affects the phenotypes of NK and dendritic cells remodeling them toward immunosuppressive phenotypes [92]

For in vitro testing purposes, urine samples were collected for secondary use from three healthy pre-menopausal women and pooled for use in the experiment

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