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At higher concentrations, MMP2 and MMP9 decrease, preventing excessive collagen degradation

Long-term use at physiological or modestly supraphysiological doses hasn't raised safety concerns in the existing literature

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At the same time, naloxone restores the values seen in the saline treated mice ( Fig

However, one factor responsible for the limited effectiveness of B cell depletors in progressive MS may be resistance of leptomeningeal inflammation to even intrathecally administered agents for reasons that are not understood (Bhargava et al., 2019)

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