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Side effect patterns

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Generally, abnormal SUA is higher in men than in women (Zhu et al., 2011

Interventions aimed at these targets may reduce vascular stiffness, lower systolic blood pressure, decrease the prevalence of ISH, and improve outcomes for patients (particularly older patients) with hypertension or other CV conditions (see, Schiffrin E L., Vascular stiffening and arterial compliance: implications for systolic blood pressure

Vitamin B12 is water-soluble, so excess is excreted naturally

Take 1 tablespoon (15 mL) daily, preferably on an empty stomach or before exercise