In tolerance assay, at 42 h after the end of conditioning regimen, shorter preconvulsive latencies than in healthy (non-diazepam conditioned) mice following isoniazid (800 mg/kg i.p.) (as hallmark of tolerance) were observed if diazepam (5.0 mg/kg i.p.) was again given acutely to mice previously conditioned with diazepam alone (use of picrotoxin 3.0 mg/kg i.p., as convulsant, with acute application of diazepam in previously diazepam conditioned mice did not lead to tolerance hallmark)
This approach has been designed to determine the maximum suggested starting dose, even though lower starting doses may also be suitable in some first-in-human clinical trials
Epidemiology of non-alcoholic fatty liver disease
Management typically involves estrogen monitoring through blood tests and, when necessary, aromatase inhibitors or selective estrogen receptor modulators
Spiking cortisol often leads to tight, tense muscles
Chandys hypothesis that a sudden influx of B12 can trigger repair processes
