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Glutathione is naturally produced in the body and plays a vital role in detoxification, immunity, and skin health

Abstract Glutathione (GSH), the most abundant intracellular low molecular weight thiol, has diverse physiological roles, and altered GSH status has been implicated in a number of chronic, acute, and age-related diseases, as well as the aging process itself

At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta

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Among them, C1-27 was one of the most potent GSTO1 inhibitors (Fig