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Compliance was measured by asking participants to report the time and conditions of the investigational product consumption on a paper diary and assessed during the site visits

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LCMS analysis of TCA cycle metabolites showed that ABHD11 loss resulted in 2-OG and 2-HG accumulation as expected 16,23 , and in line with the effects of ML226 (Fig

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These results reflect the important role of mitochondria redox status in the functioning of the cardiovascular system, as well as the possibility of its restoration in aging by the introduction of exogenous glutathione

The upregulation of the protein known as actin keeps the structural integrity of cells intact and allows them to function properly [14]