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The method optimization takes into account the functional data of GP complex: 1) the peroxilipid is reduced by GSH (reduced glutathione) to hydroxilipids (GP activity)

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

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Aqueous solvents such as sterile water or bacteriostatic water are preferred for in vivo rodent studies because they eliminate the confounding variable of DMSO's own biological activity, which includes membrane permeabilization and anti-inflammatory effects

This dual activation leads to improved insulin sensitivity, enhanced insulin secretion, and reduced appetite

doi: 10.3390/tomography9020041 75 AllisonSCJoeGGaryTSToddEPJenniferGWTiffanyLHet al