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Regulation of g-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione

The activation of the Nrf2 pathway triggers a massive endogenous production of Phase II detoxification enzymes, including Heme Oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)

Vesicular and nanocarrier-based approaches, especially those employing liposomes, have shown significant promise in augmenting transdermal drug delivery by boosting drug stability, penetration, and release kinetics

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