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In vitro studies have demonstrated that DFO can inhibit the degradation of type II collagen in osteoarthritis cartilage while also reducing the expression of inflammatory factors such as MMP-1, MMP-13, IL-1, and TNF- (Tchetina et al., 2016)

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The menisci that provide knee stability and shock absorption can degenerate, extrude, develop tears, or completely wear away

Pathway enrichment and network analyses further indicated alterations in amino acid metabolism, glutathione metabolism, and polyamine-related pathways following intervention