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121 Mis-metalation of Fur by Mn II under conditions of Mn II toxicity, in contrast, is detrimental to cell viability, and is avoided by proper tuning of the coordinated responses of the Mn II -sensing repressor and Fur to distinct ranges of cellular metal activity (Figure 8A)

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Other factors, including hormonal changes, UV cumulative damage, declining stem cell function, and altered immune function, contribute to skin aging independently of GHK levels

Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM

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Metabolite production was quantified by LC/MS/MS API3000 and normalized to total cell protein