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The reverse transporter protein System X C - , which operates as a heterodimeric complex of SLC7A11 and SLC3A2, enables the exchange of cystine and glutamate across the plasma membrane (56)

These effects are generally mild to moderate, transient, and show improvement as patients adapt to treatment

This study also showed that combining SFN with DOX allowed for a 50% reduction in DOX dosage while maintaining its anticancer effects

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