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By being informed and proactive, smokers can make smarter decisions for their well-being while reducing exposure to the most dangerous chemicals found in traditional cigarettes

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found an IC50 of 42 M for nicotine with OCT2 expressed in Xenopus oocytes ( In vivo experiments have demonstrated that nicotine can induce the activity of various enzymes within the central nervous system (CNS), including CYP2E1, CYP2A1/2A2, and CYP2B1/2B2 (Zevin and Benowitz, 1999)

Another dirty little NRT industry secret revealed in the November study was that 36.6% of those using the nicotine gum are now classified as chronic long-term users