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ABC transporter and CYP genes were upregulated in ivermectin resistant samples in a few of the included studies

Darkening of skin is a relatively common problem

However, tirzepatide 5 mg produced greater weight loss (-7.8 kg vs -5.7 kg), so it is not a true equivalency

Further studies are warranted to confirm these effects

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TP508 has also been investigated as a potential countermeasure for radiation-induced gastrointestinal injury due to its potential role in supporting intestinal stem cell regeneration.