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In regard to DPI, we previously demonstrated that low micromolar concentrations effectively reduced tumor growth and metastasis in a MYCN-driven zebrafish model of NB, with low associated toxicity ( A limitation of this study is the discrepancy between the strong in vitro synergy of the MitoQ + DPI combination and its limited effectiveness in in vivo models of NB

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[Abstract] The MMP-2 mRNA level in the HFSFs treated with glutathione oxidized (GLU, 2.48 mg/mL, 24 h) was 2.46 times greater than that in the ARP-100 (ARP, 100 M, 24 h)-treated HFSFs

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