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The major obstacles to developing probes that can monitor GSH dynamics include the reaction reversibility and kinetics of the sensing reaction, as well as the high abundance of GSH (110 mM) inside cells

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In the human liver interactome, there is greater involvement of the proteins involved in lipid metabolism and various components involved in immune response activation and receptor-mediated endocytosis

[DOI] [PMC free article] [PubMed] [Google Scholar] Encinas J.M., Michurina T.V., Peunova N., Park J.H., Tordo J., Peterson D.A., Fishell G., Koulakov A., Enikolopov G

This chronic state of severe oxidative stress damages cellular membranes through a destructive process known as lipid peroxidation, creating a highly toxic internal cellular environment

521 PURE might also enable studies on nonspecific decoding of codons through wobble-base pairing, which might highlight how new genetic codes might be used for more accurate ncAA incorporation