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120 MaityS.RahS.SonenbergN.GkogkasC
Pharmacological Inhibitors of the NLRP3 Inflammasome
Once activated by their ligands, they undergo a conformational change, promoting their release from chaperone proteins and facilitating their dimerization and translocation to the nucleus, where they bind to specific regions of DNA called hormone response elements, to recruit co-regulators, chromatin remodelers, and the transcription machinery [for review (63, 64)]
This is because ice crystal formation and repeated freeze-thaw cycles can cause aggregation, denaturation, or structural disruption
Molecules 22(4):439 Ondua M, Njoya EM, Abdalla MA, McGaw LJ (2019) Anti-inflammatory and antioxidant properties of leaf extracts of eleven South African medicinal plants used traditionally to treat inflammation
[DOI] [PubMed] [Google Scholar] 30.Liang Y, Duan L, Xiong J, Zhu W, Liu Q, Wang D, Liu W, Li Z, Wang D
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