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Some tobacco harm reduction strategies aim to decrease mortality and morbidity without eliminating tobacco and nicotine use by replacing traditional cigarette smoking by potentially reduced-exposure products (PREPs)

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Since PARP-1 activation is a prerequisite to initiate the parthanatos pathway 23 , we treated HBE cultures with the selective PARP-1 inhibitor BMN673 currently in clinical trials for cancer treatment 27 and exposed the cells to mainstream smoke

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