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MOTS-c expression levels increase in skeletal muscles, systemic circulation, and the hypothalamus upon exercise

No significant adverse effects have been reported in clinical use at therapeutic doses

Other studies have demonstrated the expression of growth hormone receptor at both the mRNA and protein levels and have shown that BPC 157 regulates the phosphorylation of extracellular-signal-regulated kinases 1 and 2 (ERK1/2) as well as their downstream targets, including c-Fos, c-Jun, and Egr-1, key molecules involved in cell growth, migration, and angiogenesis[11,25-29]

These elevations are dose-dependent and generally short-term

J., Baker, C