Furthermore, the combination of Cu 2+ and Qu synergistically activated endothelial cells and promotes angiogenesis in the skin to provide sufficient nutrients for the hair loss area and create a favorable growth environment for hair follicle regeneration, while Zn 2+ acts as an enhancer of the Cu 2+ and Qu in angiogenesis
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reported that DHODH (Dihydroorotate dehydrogenase) coordinates with GPX4 by reducing ubiquitin formation in cancer cells, blocking the action of ferroptosis in mitochondrial intima [52], DHODH inhibitors induce ferroptosis and significantly inhibit tumor growth in solid tumors with low GPX4 expression, and the combination of ferroptosis inducer sulfasalazine and DHODH inhibitors has a good therapeutic effect in solid tumors with high GPX4 expression
doi: 10.1007/s00394-017-1445-8 Summary Keywords antioxidant, bioavailability, biological properties, immunological properties, polyphenols Citation Saad AM, Mohammed DM, Alkafaas SS, Ghosh S, Negm SH, Salem HM, Fahmy MA, Semary HE, Ibrahim EH, AbuQamar SF, El-Tarabily KA and El-Saadony MT (2025) Dietary polyphenols and human health: sources, biological activities, nutritional and immunological aspects, and bioavailability a comprehensive review
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