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doi:10.3390/biom12010129 Pogribna M, Melnyk S, Pogribny I, Chango A, Yi P, James SJ

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Due to the high concentration of GABA A receptors in the basolateral amygdala, infusion of GABAergic neurosteroids, such as ALLO into this brain region interferes with the acquisition and expression of the contextual and auditory cue-induced freezing responses in male rats (246)

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Remarkably, beneficial effects have been observed across this 100-fold range, suggesting a wide therapeutic window where smaller doses remain biologically active

the authors attributed this result to the lipid extraction pretreatment boosting the ORR active center by increasing its pyridinic N (27.8%) and graphitic N (40.3%) contents