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A 2025 narrative review that pooled 70 studies on the physiology of microneedling identified the main mechanisms as collagen and elastin production, angiogenesis or new blood vessel formation, a transient rise in skin permeability, and, notably, improved epidermal barrier function once the recovery phase completes

The duration varies based on the deficiency cause, symptom severity, and patient response

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Johnson RM et al

Chemical burns can continue damaging tissue until the causative agent is completely neutralized or removed

The 20.9% mean reduction at 72 weeks exceeds the 14.9% (or 18.7% in completers) seen with survodutide at 46 weeks