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In an aqueous environment, hydrophobic portions of other molecules often enter the hydrophobic cavity of cyclodextrin to form inclusion compounds

Forms of B12 supplements available include: Cyanocobalamin : The most common and cost-effective form in over-the-counter supplements Methylcobalamin : A naturally occurring form, often marketed as superior though evidence for clinical advantage is limited Hydroxocobalamin : The preferred form for intramuscular injection in the UK, used therapeutically for pernicious anaemia and confirmed deficiency [4] Dosing considerations depend on the indication

Kawakami, S

B12 has a very low toxicity, so large amounts are not considered dangerous

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